Ananth Annapragada, PhD, Professor of Radiology and Director of Basic Research in the Edward B. Singleton Department of Pediatric Radiology at Texas Childrens Hospital presents at the recent Human Placenta Project at NIH .
Prof. Annapragada provides data comparing Aspect 1.0 Tesla MRI images with data from a competitors high field 9.4 Tesla.
The Aspect 1.0T image data shows the exquisite high quality research that can be performed at lower fields and that for certain experiments higher field is not necessary.
Abstract
PET/MRI is an emerging field in medical research. We evaluated the potential of the ICON compact MRI system within a combined PET/MRI setup and provide various examples for in vivo PET/MRI studies. Application examples include cardiovascular disease, inflammation and arthritis and cancer biology in vivo. The unique attributes of this compact, high-performance MRI system – – with no external magnetic field and the possibility for placement anywhere in a biological lab – – will be discussed as a biological imaging tool, as well as a flexible instrument in a multi-modality imaging core facility.
Keywords
Multi-Modality, Cancer, Cardiology, Inflammation, PET – MRI, PET/MRI, Arthritis
Applications
Multi-Modality, Cancer, Cardiology, Inflammation, Arthritis
Abstract
Compact, desktop MRI systems enable biologists to benefit from the 3D morphological imaging benefits of MRI without the cost, complexity and expertise required to operate high-field superconducting MRI systems. Dr. Johnson details many of these benefits and provides specific details on the use of the M2 compact high-performance MRI system for longitudinal studies of mice models of Human Colorectal Carcinoma and Glioblastoma.
NOTE: This presentation described the Aspect Imaging M2™ compact high-performance MRI system. The system is now available as the Bruker ICON, the standard in pre-clinical compact MRI platforms. The ICON uses Aspect Imaging’s compact magnet, gradients and animal handling systems.
Keywords
Cancer, Neurology, Human Colorectal Carcinoma, Glioblastoma
Applications
Cancer, Neurology
Abstract
While valuable as independent tools, imaging scanners can be coupled together in research applications to provide a richer understanding of the anatomical, functional, and molecular mechanisms driving disease and drug efficacy. The work associated with these experiments must add value to the project without crippling experiment throughput. Dr. Silva will explore the value of compact MRI integrated into multi-modal laboratory with emphasis on bioluminescence and nuclear medicine examples.
Keywords
Cancer, Multi-Modality, Drug Development, LumiQuant, Bioluminescence
Applications
Cancer, Multi-Modality, Drug Development
Abstract
Dr. Jaffray will discuss the approach of the multi-disciplinary STTARR Facility in Toronto, Canada in how it integrates imaging and intervention from a radiological and pharmaceutical perspective including image-guided drug delivery. Specifically, Dr. Jaffray will review how his research leverages the ICON compact MRI system within the context of multi-modality imaging to better understand and guide radiation therapy.
Keywords
Multi-Modality, Image-guided radiation therapy, drug development
Applications
Multi-Modality
Abstract
The development of compact MRI technology has increased the accessibility of this modality for cancer researchers interested in experimental therapeutics. In order to assess the utility of compact MR for use in this setting, several tumor models were evaluated using a variety of imaging sequences, including genetically engineered models of pancreatic cancer, bladder cancer, prostate cancer, glioma, and others. Dr. Olive will review the results of 3D tumor volume reconstructions to monitor response to therapy, as well as contrast imaging applications.
Keywords
Cancer, Pancreatic Cancer, Therapeutic Response
Applications
Cancer, Pancreatic Cancer, Contrast Agents
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